Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
TESK2
Introduction
Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.[1][2]
Function
Function
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meiotic stages and/or early stages of spermiogenesis.[2]
References
References
- ↑ Røsok O, Pedeutour F, Ree AH, Aasheim HC (October 1999). “Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis”. Genomics. 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.
- ↑ 2.0 2.1 “Entrez Gene: TESK2 testis-specific kinase 2”.
Further reading
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). “Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1”. The Journal of Biological Chemistry. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
- Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (August 2001). “Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells”. The Journal of Biological Chemistry. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.