Health Dictionary
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THBS1
Introduction
Thrombospondin 1, also known as THBS1, is a human gene.
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.[1]
Further reading
Further reading
- Roberts DD (1996). “Regulation of tumor growth and metastasis by thrombospondin-1”. FASEB J. 10 (10): 1183–91. PMID 8751720.
- Adams JC (1997). “Thrombospondin-1”. Int. J. Biochem. Cell Biol. 29 (6): 861–5. PMID 9304800.
- Sargiannidou I, Qiu C, Tuszynski GP (2004). “Mechanisms of thrombospondin-1-mediated metastasis and angiogenesis”. Semin. Thromb. Hemost. 30 (1): 127–36. doi:10.1055/s-2004-822977. PMID 15034804.
- Esemuede N, Lee T, Pierre-Paul D; et al. (2004). “The role of thrombospondin-1 in human disease”. J. Surg. Res. 122 (1): 135–42. doi:10.1016/j.jss.2004.05.015. PMID 15522326.
- Li Z, Wang C, Prendergast GC, Pestell RG (2007). “Cyclin D1 functions in cell migration”. Cell Cycle. 5 (21): 2440–2. PMID 17106256.
- Roberts DD, Isenberg JS, Ridnour LA, Wink DA (2007). “Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis”. Clin. Cancer Res. 13 (3): 795–8. doi:10.1158/1078-0432.CCR-06-1758. PMID 17289869.
- Kaczorowski DJ, Billiar TR (2007). “Targeting CD47: NO limit on therapeutic potential”. Circ. Res. 100 (5): 602–3. doi:10.1161/01.RES.0000261609.44977.25. PMID 17363705.