Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
TICAM2
Introduction
TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene.[1]
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM][1]
Further reading
Further reading
- Sullivan C, Postlethwait JH, Lage CR, et al. (2007). “Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates”. J. Immunol. 178 (7): 4517–27. doi:10.4049/jimmunol.178.7.4517. PMID 17372010.
- Rowe DC, McGettrick AF, Latz E, et al. (2006). “The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction”. Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6299–304. doi:10.1073/pnas.0510041103. PMC 1458872. PMID 16603631.
- Yamamoto M, Sato S, Hemmi H, et al. (2003). “TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway”. Nat. Immunol. 4 (11): 1144–50. doi:10.1038/ni986. PMID 14556004.
- Oshiumi H, Sasai M, Shida K, et al. (2004). “TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta”. J. Biol. Chem. 278 (50): 49751–62. doi:10.1074/jbc.M305820200. PMID 14519765.
- Fitzgerald KA, Rowe DC, Barnes BJ, et al. (2003). “LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF”. J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278.
- Matsuda A, Suzuki Y, Honda G, et al. (2003). “Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways”. Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
- Bin LH, Xu LG, Shu HB (2003). “TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling”. J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lai CH, Chou CY, Ch’ang LY, et al. (2000). “Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics”. Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.