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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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TIE1

Introduction

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.[1]

Function

Function

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells[2] and platelets.[3] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.[4]

See also

See also

References

References

  1. ↑ Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). “A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains”. Molecular and Cellular Biology. 12 (4): 1698–707. PMC 369613. PMID 1312667.
  2. ↑ Rodewald HR, Sato TN (January 1996). “Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells”. Oncogene. 12 (2): 397–404. PMID 8570217.
  3. ↑ Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). “Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets”. Journal of Vascular Research. 37 (6): 437–42. doi:10.1159/000054075. PMID 11146396.
  4. ↑ Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). “Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules”. Biochemical and Biophysical Research Communications. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.
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