Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
TNPO2
Introduction
Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.[1][2][3]
Interactions
Interactions
TNPO2 has been shown to interact with NXF1,[2] NUP98[4] and Ran (biology).[2]
References
References
- ↑ Siomi MC, Eder PS, Kataoka N, Wan L, Liu Q, Dreyfuss G (October 1997). “Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins”. J Cell Biol. 138 (6): 1181–92. doi:10.1083/jcb.138.6.1181. PMC 2132560. PMID 9298975.
- ↑ 2.0 2.1 2.2 Shamsher MK, Ploski J, Radu A (October 2002). “Karyopherin beta 2B participates in mRNA export from the nucleus”. Proc Natl Acad Sci U S A. 99 (22): 14195–9. Bibcode:2002PNAS…9914195S. doi:10.1073/pnas.212518199. PMC 137860. PMID 12384575.
- ↑ “Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b)”.
- ↑ Fontoura, B M; Blobel G; Yaseen N R (October 2000). “The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import”. J. Biol. Chem. UNITED STATES. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. ISSN 0021-9258. PMID 10875935.
Further reading
Further reading
- Gallouzi IE, Steitz JA (2001). “Delineation of mRNA export pathways by the use of cell-permeable peptides”. Science. 294 (5548): 1895–901. Bibcode:2001Sci…294.1895G. doi:10.1126/science.1064693. PMID 11729309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS…9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Blanc V, Kennedy S, Davidson NO (2003). “A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling”. J. Biol. Chem. 278 (42): 41198–204. doi:10.1074/jbc.M302951200. PMID 12896982.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Güttinger S, Mühlhäusser P, Koller-Eichhorn R, et al. (2004). “Transportin2 functions as importin and mediates nuclear import of HuR”. Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2918–23. Bibcode:2004PNAS..101.2918G. doi:10.1073/pnas.0400342101. PMC 365720. PMID 14981248.
- Rebane A, Aab A, Steitz JA (2004). “Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR”. RNA. 10 (4): 590–9. doi:10.1261/rna.5224304. PMC 1370549. PMID 15037768.
- Lee BJ, Cansizoglu AE, Süel KE, et al. (2006). “Rules for nuclear localization sequence recognition by karyopherin beta 2”. Cell. 126 (3): 543–58. doi:10.1016/j.cell.2006.05.049. PMC 3442361. PMID 16901787.
- Ewing RM, Chu P, Elisma F, et al. (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMCÂ 1847948. PMIDÂ 17353931.