Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
TRERF1
Introduction
Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.[1][2]
This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.[2]
Interactions
Interactions
TRERF1 has been shown to interact with Steroidogenic factor 1,[3] EP300[1] and CREB-binding protein.[1]
References
References
- ↑ 1.0 1.1 1.2 Gizard F, Lavallee B, DeWitte F, Hum DW (Sep 2001). “A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression”. J Biol Chem. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124.
- ↑ 2.0 2.1 “Entrez Gene: TRERF1 transcriptional regulating factor 1”.
- ↑ Gizard, Florence; Lavallee Bernard; DeWitte Frederique; Teissier Elisabeth; Staels Bart; Hum Dean W (Oct 2002). “The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells”. J. Biol. Chem. United States. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. ISSN 0021-9258. PMID 12101186.
Further reading
Further reading
- Dorssers LC, Veldscholte J (1997). “Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells”. Int. J. Cancer. 72 (4): 700–5. doi:10.1002/(SICI)1097-0215(19970807)72:4<700::AID-IJC24>3.0.CO;2-D. PMID 9259413.
- Gizard F, Lavallee B, DeWitte F, et al. (2002). “The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells”. J. Biol. Chem. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186.
- Gizard F, El-Alfy M, Duguay Y, et al. (2003). “Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression”. Endocr. Res. 28 (4): 559–74. doi:10.1081/ERC-120016841. PMID 12530663.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). “The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gizard F, Teissier E, Dufort I, et al. (2005). “The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells”. J. Mol. Endocrinol. 32 (2): 557–69. doi:10.1677/jme.0.0320557. PMID 15072559.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gizard F, Robillard R, Barbier O, et al. (2005). “TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1”. Mol. Cell. Biol. 25 (11): 4335–48. doi:10.1128/MCB.25.11.4335-4348.2005. PMC 1140623. PMID 15899840.
- Gizard F, Robillard R, Gross B, et al. (2006). “TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone”. Mol. Cell. Biol. 26 (20): 7632–44. doi:10.1128/MCB.00326-06. PMC 1636875. PMID 17015480.