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TSEN54 (gene)
Introduction
TRNA splicing endonuclease subunit 54 is a protein that in humans is encoded by the TSEN54 gene. [1]
Function
Function
This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the removal of introns from precursor tRNAs. The complex is also implicated in pre-mRNA 3-prime end processing.
Clinical significance
Clinical significance
Mutations in this gene result in pontocerebellar hypoplasia type 2.
References
References
- ↑ “Entrez Gene: TRNA splicing endonuclease subunit 54”. Retrieved 2016-10-18.
Further reading
Further reading
- Budde BS, Namavar Y, Barth PG, Poll-The BT, Nürnberg G, Becker C, van Ruissen F, Weterman MA, Fluiter K, te Beek ET, Aronica E, van der Knaap MS, Höhne W, Toliat MR, Crow YJ, Steinling M, Voit T, Roelenso F, Brussel W, Brockmann K, Kyllerman M, Boltshauser E, Hammersen G, Willemsen M, Basel-Vanagaite L, Krägeloh-Mann I, de Vries LS, Sztriha L, Muntoni F, Ferrie CD, Battini R, Hennekam RC, Grillo E, Beemer FA, Stoets LM, Wollnik B, Nürnberg P, Baas F (2008). “tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia”. Nat. Genet. 40 (9): 1113–8. doi:10.1038/ng.204. PMID 18711368.
- Cassandrini D, Biancheri R, Tessa A, Di Rocco M, Di Capua M, Bruno C, Denora PS, Sartori S, Rossi A, Nozza P, Emma F, Mezzano P, Politi MR, Laverda AM, Zara F, Pavone L, Simonati A, Leuzzi V, Santorelli FM, Bertini E (2010). “Pontocerebellar hypoplasia: clinical, pathologic, and genetic studies”. Neurology. 75 (16): 1459–64. doi:10.1212/WNL.0b013e3181f88173. PMID 20956791.
- Maricich SM, Aqeeb KA, Moayedi Y, Mathes EL, Patel MS, Chitayat D, Lyon G, Leroy JG, Zoghbi HY (2011). “Pontocerebellar hypoplasia: review of classification and genetics, and exclusion of several genes known to be important for cerebellar development”. J. Child Neurol. 26 (3): 288–94. doi:10.1177/0883073810380047. PMID 21383226.
- Simonati A, Cassandrini D, Bazan D, Santorelli FM (2011). “TSEN54 mutation in a child with pontocerebellar hypoplasia type 1”. Acta Neuropathol. 121 (5): 671–3. doi:10.1007/s00401-011-0823-1. PMID 21468723.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.