Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
TTI2
Introduction
TELO2 interacting protein 2 is a protein that in humans is encoded by the TTI2 gene. [1]
Function
Function
This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.
Further reading
Further reading
- Hurov KE, Cotta-Ramusino C, Elledge SJ (2010). “A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability”. Genes Dev. 24 (17): 1939–50. doi:10.1101/gad.1934210. PMC 2932975. PMID 20810650.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.