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Tachykinin receptor
Introduction
There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).
Binding
Binding
The genes and receptor ligands are as follows:[1]
| Receptor | Gene | Preferred ligand |
| NK1 | TACR1 | substance P |
| NK2 | TACR2 | neurokinin A |
| NK3 | TACR3 | neurokinin B |
(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
References
References
- ↑ Maggi CA (September 1995). “The mammalian tachykinin receptors”. General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.
External links
External links
- “Tachykinin Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Tachykinin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)