Singh-Williams-McAlister syndrome
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Talo-patello-scaphoid osteolysis
Overview
Overview
Singh-Williams-McAlister syndrome[1] is a rare syndrome characterized by the resorption of bones (ankles, knees and wrists). Singh-Williams-McAlister syndrome is a syndrome belonging to the category of carpal-tarsal osteolysis diseases without nephropathy.
Pathophysiology
Pathophysiology
It is characterised by bilateral osteolysis of the tali, scaphoids, patella and short fourth metacarpals.
Genetics
Autosomal recessive inheritance is suspected.
Epidemiology and Demographics
Epidemiology and Demographics
Prevalance: <1 / 1 000 000
Diagnosis
Diagnosis
Symptoms
The osteolysis is accompanied by periarticular swelling and pain.
Treatment
Treatment
Supportive care of chronic pain is required.
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