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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Teratoma natural history

Introduction

Overview

Overview

The prognosis of teratoma depends on the type of tumor and malignant transformation. Mature teratoma is begnin and has an excellent prognosis compared to immature teratoma which has a favorable prognosis.The 6 year survival rate of patients with mature teratoma is approximately 96%. The overall 5 years survival rate of patient with immature teratoma is 90% and 75% for stage II-IV.Common complications are malignant transformation, rupture, torsion, and hemolytic anemia.

Natural History, Complications, and Prognosis

Natural History, Complications, and Prognosis

Natural History

  • The symptoms of teratoma depends on the locations of the tumors.

Complications

  • Common complications of teratoma specially ovarian teratoma include:[1][2][3]
    • Torsion
    • Rupture
    • Malignant transformation
    • Infections
    • Autoimmune hemolytic anemia

Prognosis

  • Mature teratoma has an excellent prognosis.[4]
  • The 6 year survival rate of patients with mature teratoma is approximately 96%.[5]
  • Immature teratoma has favorable prognosis for stage I and poor for advance stages.[6]
  • Immature teratoma has 90%-95% of 5 years of survival rate for stage I and 75 % for stage II-IV.[6]
References

References

  1. ↑ Park SB, Kim JK, Kim KR, Cho KS (2008). “Imaging findings of complications and unusual manifestations of ovarian teratomas”. Radiographics. 28 (4): 969–83. doi:10.1148/rg.284075069. PMID 18635624.
  2. ↑ Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (1994) Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. Obstet Gynecol 84 (1):22-8. PMID: 8008317
  3. ↑ Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A (1988). “Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary”. Singapore Med J. 29 (1): 30–4. PMID 2841767.
  4. ↑ Terenziani M, D’Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL; et al. (2015). “Mature and immature teratoma: A report from the second Italian pediatric study”. Pediatr Blood Cancer. 62 (7): 1202–8. doi:10.1002/pbc.25423. PMID 25631333.
  5. ↑ Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP; et al. (1998). “Teratomas in infancy and childhood”. Med Pediatr Oncol. 31 (1): 8–15. doi:10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h. PMID 9607423.
  6. ↑ 6.0 6.1 Mann JR, Gray ES, Thornton C, Raafat F, Robinson K, Collins GS et al. (2008) Mature and immature extracranial teratomas in children: the UK Children’s Cancer Study Group Experience. J Clin Oncol 26 (21):3590-7. DOI:10.1200/JCO.2008.16.0622 PMID: 18541896

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2]