Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Tesofensine
Introduction
Tesofensine is a serotonin-noradrenaline-dopamine reuptake inhibitor, which also seems to increase the action of acetylcholine in the brain, probably due to downstream effects. It was originally researched for the treatment of Alzheimer’s disease and Parkinson’s Disease, but was subsequently dropped from development for these applications, and is now being researched for the treatment of obesity, presumably as an appetite suppressant. As of 2006 it was in Phase II trials for the treatment of obesity.[1]