Testicular cancer laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]

Overview

An elevated concentration of blood tumor marker tests is diagnostic of testicular cancer.

Laboratory Tests

Tumor marker tests:^[1]^[2]

Tumor type	Tumor markers
Tumor type	Human chorionic gonadotropin (HCG)	Alpha-fetoprotein (AFP)	Lactate dehydrogenase (LDH)
Seminoma	↑	–	↑
Choriocarcinoma	↑↑	–	↑
Yolk sac tumor	–	↑	↑
Embryonal tumor	↑	↑	↑
Teratoma	–	↑	↑

Sex cord stromal testicular tumor

Leydig cell tumor^[3]

Sertoli cell tumor^[3]

References

↑ Milose JC, Filson CP, Weizer AZ, Hafez KS, Montgomery JS (December 2011). “Role of biochemical markers in testicular cancer: diagnosis, staging, and surveillance”. Open Access J Urol. 4: 1–8. doi:10.2147/OAJU.S15063. PMC 3818947. PMID 24198649.
↑ Gilligan TD, Seidenfeld J, Basch EM, Einhorn LH, Fancher T, Smith DC, Stephenson AJ, Vaughn DJ, Cosby R, Hayes DF (July 2010). “American Society of Clinical Oncology Clinical Practice Guideline on uses of serum tumor markers in adult males with germ cell tumors”. J. Clin. Oncol. 28 (20): 3388–404. doi:10.1200/JCO.2009.26.4481. PMID 20530278.
↑ ^3.0 ^3.1 Al-Agha OM, Axiotis CA (February 2007). “An in-depth look at Leydig cell tumor of the testis”. Arch. Pathol. Lab. Med. 131 (2): 311–7. doi:10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2. PMID 17284120.

Overview