Health Dictionary
Reliable, easy-to-read patient information on common medical conditions β written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Testotoxicosis
Introduction
Familial male precocious puberty (also known as testotoxicosis) is a form of gonadotropin-independent precocious puberty in which boys experience early onset and progression of puberty. Signs of puberty can develop as early as an age of 1 year.
The ο¬nal length of boys may be short due to a rapid advance in epiphyseal maturation. It is an autosomal dominant condition with a mutation of the LH receptor. Treatment is with drugs that suppress gonadal steroidogenesis, such as cyproterone acetate, ketoconazole or spironolactone and testolactone.
References
References
- Traggiai C, Stanhope R (2003). “Disorders of pubertal development”. Best Pract Res Clin Obstet Gynaecol. 17 (1): 41β56. PMID 12758225.
- Reiter EO, Norjavaara E (2005). “Testotoxicosis: current viewpoint”. Pediatr Endocrinol Rev. 3 (2): 77β86. PMID 16361981.