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ThioTEPA
Introduction
Overview
Overview
N,N’N’-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N’,N”- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.
References
References
- Sykes M; et al. (1953). “Clinical Studies of triethylenephosphoramide compounds with nitrogen mustard-like activity”. Cancer. 6: 142–48.
- Maanen MJ, Smeets CJ, Beijnen JH (2000). “Chemistry, pharmacology and pharmacokinetics of N,N’,N” -triethylenethiophosphoramide (ThioTEPA)”. Cancer Treat Rev. 26 (4): 257–68. PMID 10913381.