ThioTEPA

N,N’N’-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N’,N”- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.

• Sykes M; et al. (1953). “Clinical Studies of triethylenephosphoramide compounds with nitrogen mustard-like activity”. Cancer. 6: 142–48.CS1 maint: Explicit use of et al. (link)
• Maanen MJ, Smeets CJ, Beijnen JH (2000). “Chemistry, pharmacology and pharmacokinetics of N,N’,N” -triethylenethiophosphoramide (ThioTEPA)”. Cancer Treat Rev. 26 (4): 257–68. PMID 10913381.CS1 maint: Multiple names: authors list (link)

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