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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Thrombotic thrombocytopenic purpura overview

Introduction

Overview

Overview

Thrombotic thrombocytopenic purpura (TTP or Moschcowitz disease) is a rare disorder of the blood-coagulation system, causing multiple blood clots to form in blood vessels around the body.[1] Most cases of TTP arise from deficiency or inhibition of the enzyme ADAMTS13, which is responsible for cleaving large multimers of von Willebrand factor.[2] This leads to hemolysis and end-organ damage, and may require plasmapheresis therapy.

References

References

  1. ↑ “MedlinePlus: Thrombotic thrombocytopenic purpura”, MedlinePlus Medical Encyclopedia, 2007, webpage: NLM-552.
  2. ↑ Moake JL (2004). “von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura”. Semin. Hematol. 41 (1): 4–14. PMID 14727254.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]