Thrombotic thrombocytopenic purpura overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

Thrombotic thrombocytopenic purpura (TTP or Moschcowitz disease) is a rare disorder of the blood-coagulation system, causing multiple blood clots to form in blood vessels around the body.^[1] Most cases of TTP arise from deficiency or inhibition of the enzyme ADAMTS13, which is responsible for cleaving large multimers of von Willebrand factor.^[2] This leads to hemolysis and end-organ damage, and may require plasmapheresis therapy.

References

↑ “MedlinePlus: Thrombotic thrombocytopenic purpura”, MedlinePlus Medical Encyclopedia, 2007, webpage: NLM-552.
↑ Moake JL (2004). “von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura”. Semin. Hematol. 41 (1): 4–14. PMID 14727254.

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[MedPlus-1] “MedlinePlus: Thrombotic thrombocytopenic purpura”, MedlinePlus Medical Encyclopedia, 2007, webpage: NLM-552.

[2] Moake JL (2004). “von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura”. Semin. Hematol. 41 (1): 4–14. PMID 14727254.

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Thrombotic thrombocytopenic purpura overview

Overview

References

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