Thrombotic thrombocytopenic purpura risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

The most potent risk factor in the development of TTP is black ethnicity. Other risk factors include famale gender, pregnancy, obseity, chemotherapy, infection and etc.

Risk Factors

Common Risk Factors

Common risk factors in the development of TTP include:^[1]^[2]^[3]

Black ethnicity
Female gender
SLE
Obesity
Pregnancy (third trimester)
Cancer therapies
Infection (HIV)
Surgery (bone marrow stem cell transplant)
Medicines :chemotherapy, hormone replacement therapy(estrogens)

Less Common Risk Factors

Less common risk factors in the development of TTP include:^[1]^[4]^[5]^[6]

References

↑ ^1.0 ^1.1 Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P (2016). “Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors”. PLoS ONE. 11 (7): e0156679. doi:10.1371/journal.pone.0156679. PMC 4934773. PMID 27383202.
↑ Nicol, Kathleen K.; Shelton, Brent J.; Knovich, Mary Ann; Owen, John (2003). “Overweight individuals are at increased risk for thrombotic thrombocytopenic purpura”. American Journal of Hematology. 74 (3): 170–174. doi:10.1002/ajh.10418. ISSN 0361-8609.
↑ Scully M, Thomas M, Underwood M, Watson H, Langley K, Camilleri RS, Clark A, Creagh D, Rayment R, Mcdonald V, Roy A, Evans G, McGuckin S, Ni Ainle F, Maclean R, Lester W, Nash M, Scott R, O Brien P (July 2014). “Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes”. Blood. 124 (2): 211–9. doi:10.1182/blood-2014-02-553131. PMID 24859360.
↑ Visagie GJ, Louw VJ (August 2010). “Myocardial injury in HIV-associated thrombotic thrombocytopenic purpura (TTP)”. Transfus Med. 20 (4): 258–64. doi:10.1111/j.1365-3148.2010.01006.x. PMID 20409074.
↑ Jodele S, Laskin BL, Dandoy CE, Myers KC, El-Bietar J, Davies SM, Goebel J, Dixon BP (May 2015). “A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury”. Blood Rev. 29 (3): 191–204. doi:10.1016/j.blre.2014.11.001. PMC 4659438. PMID 25483393.
↑ Uderzo C, Fumagalli M, De Lorenzo P, Busca A, Vassallo E, Bonanomi S, Lanino E, Dini G, Varotto S, Messina C, Miniero R, Valsecchi MG, Balduzzi A (November 2000). “Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing bone marrow transplantation”. Bone Marrow Transplant. 26 (9): 1005–9. doi:10.1038/sj.bmt.1702648. PMID 11100281.

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[pmid27383202-1] 1.0 ^1.1 Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P (2016). “Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors”. PLoS ONE. 11 (7): e0156679. doi:10.1371/journal.pone.0156679. PMC 4934773. PMID 27383202.

[NicolShelton2003-2] Nicol, Kathleen K.; Shelton, Brent J.; Knovich, Mary Ann; Owen, John (2003). “Overweight individuals are at increased risk for thrombotic thrombocytopenic purpura”. American Journal of Hematology. 74 (3): 170–174. doi:10.1002/ajh.10418. ISSN 0361-8609.

[pmid24859360-3] Scully M, Thomas M, Underwood M, Watson H, Langley K, Camilleri RS, Clark A, Creagh D, Rayment R, Mcdonald V, Roy A, Evans G, McGuckin S, Ni Ainle F, Maclean R, Lester W, Nash M, Scott R, O Brien P (July 2014). “Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes”. Blood. 124 (2): 211–9. doi:10.1182/blood-2014-02-553131. PMID 24859360.

[pmid20409074-4] Visagie GJ, Louw VJ (August 2010). “Myocardial injury in HIV-associated thrombotic thrombocytopenic purpura (TTP)”. Transfus Med. 20 (4): 258–64. doi:10.1111/j.1365-3148.2010.01006.x. PMID 20409074.

[pmid25483393-5] Jodele S, Laskin BL, Dandoy CE, Myers KC, El-Bietar J, Davies SM, Goebel J, Dixon BP (May 2015). “A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury”. Blood Rev. 29 (3): 191–204. doi:10.1016/j.blre.2014.11.001. PMC 4659438. PMID 25483393.

[pmid11100281-6] Uderzo C, Fumagalli M, De Lorenzo P, Busca A, Vassallo E, Bonanomi S, Lanino E, Dini G, Varotto S, Messina C, Miniero R, Valsecchi MG, Balduzzi A (November 2000). “Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing bone marrow transplantation”. Bone Marrow Transplant. 26 (9): 1005–9. doi:10.1038/sj.bmt.1702648. PMID 11100281.

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