Thromboxane

Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2.

Thromboxane is named for its role in clot formation (thrombosis).

It is produced in platelets by thromboxane-A synthase from the endoperoxides produced by the cyclooxygenase (COX) enzyme from arachidonic acid.

Thromboxane acts by binding to any of the thromboxane receptors, G-protein coupled receptors coupled to the G protein G_q^[1].

Thromboxane is a vasoconstrictor and a potent hypertensive agent, and it facilitates platelet aggregation.

It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The mechanism of secretion of thromboxanes from platelets is still unclear.

Thromboxane A₂ (TXA₂), produced by activated platelets, has prothrombotic properties, stimulating activation of new platelets as well as increasing platelet aggregation.

Platelet aggregation is achieved by mediating expression of the glycoprotein complex GP IIb/IIIa in the cell membrane of platelets. Circulating fibrinogen binds these receptors on adjacent platelets, further strengthening the clot.

It is believed that the vasoconstriction caused by thromboxanes plays a role in Prinzmetal’s angina.

The widely used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets.

It inhibits the COX enzyme both non-competitively and irreversibly.

The side effect of this is that people who regularly take aspirin will suffer from excessive bleeding whenever the skin is perforated.

• Thromboxanes at the US National Library of Medicine Medical Subject Headings (MeSH)

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