Health Dictionary
Reliable, easy-to-read patient information on common medical conditions â written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Tiaprofenic acid
Introduction
Overview
Overview
Tiaprofenic acid is a non-steroidal anti-inflammatory drug (NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300Â mg twice daily. It is not recommended in children.
It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine. Renal disease impairs excretion, and it should be used with caution in renal disease.
Long-term use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs.[1] It is contraindicated in patients with cystitis and urinary tract infections.
The earliest reports of clinical use are from France in 1975 [2]
It is marketed under the trade names Surgam, Surgamyl and Tiaprofen, and in generic formulations. A sustained-release preparation is available. It is isomer with Suprofen.
References
References
- â Crawford MLA, Waller PC, Wood SM (1997). “Severe cystitis associated with tiaprofenic acid”. British Journal of Urology. 79 (4): 578â584. doi:10.1046/j.1464-410X.1997.00094.x. PMIDÂ 9126086.
- â Pons J, Pasturel A (1975). “[How to improve postoperative complications in stomatological, maxillofacial and plastic surgery: evaluation of tiaprofenic acid]. [French]”. Revue d Odonto-Stomatologie. 4 (6 pages = 535-7).
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]