Ticarcillin clavulanate drug interactions

• Aminoglycosides

The mixing of TIMENTIN with an aminoglycoside in solutions for parenteral administration can result in substantial inactivation of the aminoglycoside.

• Probenecid

Probenecid interferes with the renal tubular secretion of ticarcillin, thereby increasing serum concentrations and prolonging serum half‑life of ticarcillin. Probenecid does not affect the serum levels of clavulanic acid.

• Oral Contraceptives

Ticarcillin disodium/clavulanate potassium may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.

• Effects on Laboratory Tests

High urine concentrations of ticarcillin may produce false‑positive protein reactions (pseudoproteinuria) with certain methods. The bromphenol blue reagent strip test has been reported to be a reliable method for testing protein reactions [see Warnings and Precautions].

Clavulanic acid in TIMENTIN may cause a nonspecific binding of IgG and albumin by red cell membranes, leading to a false‑positive Coombs test. A positive Coombs test should be interpreted with caution during treatment with TIMENTIN [see Warnings and Precautions].^[1]

Adapted from the FDA Package Insert.