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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Toxic megacolon epidemiology and demographics

Introduction

Overview

Overview

The precise incidence of toxic megacolon is unknown in general population. The incidence of toxic megacolon in the associated disorders including ulcerative colitis and Crohn’s disease is 1000-2500 in 100,000 cases and 4400-6300 in 100,000 cases, respectively. The mortality rate of toxic megacolon associated with Clostridium difficile is approximately 38%-80%.

Epidemiology and Demographics

Epidemiology and Demographics

Incidence

Mortality rate

  • The mortality rate of toxic megacolon associated with clostridium difficile is approximately 38%-80%.[4][5]

Age

  • Patients of all age groups may develop toxic megacolon.[6]

Race

  • There is no racial predilection described in toxic megacolon.[7]

Gender

  • Toxic megacolon affects men and women equally.[8]
References

References

  1. ↑ Gan, S. Ian; Beck, P. L. (2003). “A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management”. The American Journal of Gastroenterology. 98 (11): 2363–2371. doi:10.1111/j.1572-0241.2003.07696.x. ISSN 0002-9270.
  2. ↑ Grieco MB, Bordan DL, Geiss AC, Beil AR (1980). “Toxic megacolon complicating Crohn’s colitis”. Ann. Surg. 191 (1): 75–80. PMC 1344622. PMID 7352781.
  3. ↑ Sayedy, Leena (2010). “Toxic megacolon associatedClostridium difficilecolitis”. World Journal of Gastrointestinal Endoscopy. 2 (8): 293. doi:10.4253/wjge.v2.i8.293. ISSN 1948-5190.
  4. ↑ Hall JF, Berger D (2008). “Outcome of colectomy for Clostridium difficile colitis: a plea for early surgical management”. Am. J. Surg. 196 (3): 384–8. doi:10.1016/j.amjsurg.2007.11.017. PMID 18519126.
  5. ↑ Earhart MM (2008). “The identification and treatment of toxic megacolon secondary to pseudomembranous colitis”. Dimens Crit Care Nurs. 27 (6): 249–54. doi:10.1097/01.DCC.0000338869.70035.2b. PMID 18953191.
  6. ↑ Sheth SG, LaMont JT (1998). “Toxic megacolon”. Lancet. 351 (9101): 509–13. doi:10.1016/S0140-6736(97)10475-5. PMID 9482465.
  7. ↑ Rubin MS, Bodenstein LE, Kent KC (1995). “Severe Clostridium difficile colitis”. Dis. Colon Rectum. 38 (4): 350–4. PMID 7720439.
  8. ↑ Gan SI, Beck PL (2003). “A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management”. Am. J. Gastroenterol. 98 (11): 2363–71. doi:10.1111/j.1572-0241.2003.07696.x. PMID 14638335.
References

References


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]