Laboratory findings consistent with the diagnosis of toxic megacolon include anemia and leukocytosis. Some patients with toxic megacolon may have elevated concentration of Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), which is usually suggestive of inflammation.

• Laboratory findings consistent with the diagnosis of toxic megacolon include:^{[1][2][3][4][5]}
  • Anemia
  • Leukocytosis especially in patients with Clostridium difficile infection
  • Hypoalbuminemia
  • Metabolic alkalosis associated with a poor prognosis
  • Metabolic acidosis secondary to ischemic colitis
• Some patients with toxic megacolon may have elevated Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration.^[6][7][8][9]
• Electrolyte disturbances are common secondary to inflammatory diarrhea, steroid use and ongoing gastrointestinal losses.^{[4][10][11][12]}