Transfusion-associated graft versus host disease history and symptoms

The clinical presentation the same as in GvHD occurring in other settings, such as bone marrow transplantation. TA-GvHD can develop four to thirty days after the transfusion. Typical symptoms include:

• fever
• erythematous maculopapular rash, which can progress to generalised erythroderma
• toxic epidermal necrolysis in extreme cases

Other symptoms can include cough, abdominal pain, vomiting, and profuse diarrhea (up to 8 liters/day).

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