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Transient hypogammaglobulinemia of infancy

Introduction

Overview

Overview

Transient hypogammaglobulinemia of infancy is a form of hypogammaglobulinemia appearing after birth, leading to a reduction in the level of IgG, and also sometimes IgA[1] and IgM.[2] (The ratios of immunoglobulins vary rapidly in all infants, and the term dysgammaglobulinemia, although theoretically applicable, isn’t usually used in this context.)

It can result in increased infections, but it can also present without symptoms.[3]

Historical Perspective

Historical Perspective

Classification

Classification

Pathophysiology

Pathophysiology

Causes

Causes

Differentiating Transient hypogammaglobulinemia of infancy from Other Diseases

Differentiating Transient hypogammaglobulinemia of infancy from Other Diseases

Epidemiology and Demographics

Epidemiology and Demographics

Risk Factors

Risk Factors

Screening

Screening

Natural History, Complications, and Prognosis

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

Diagnosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Imaging Findings

Other Diagnostic Studies

Treatment

Treatment

Medical Therapy

Surgery

Prevention

References

References

  1. ↑ “Transient Hypogammaglobulinemia of Infancy: Immunodeficiency Disorders: Merck Manual Professional”. Retrieved 2008-03-01.
  2. ↑ KiliΓ§ SS, Tezcan I, Sanal O, Metin A, Ersoy F (2000). “Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases”. Pediatr Int. 42 (6): 647–50. PMIDΒ 11192522.
  3. ↑ Hsueh KC, Chiu HH, Lin HC, Hsu CH, Tsai FJ (2005). “Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection”. J Microbiol Immunol Infect. 38 (2): 141–4. PMIDΒ 15843860.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]