Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Transposition of the great vessels causes
Introduction
Overview
Overview
The causes for transposition of the great arteries is unknown and is presumed to be multifactorial. The embryology likely involves abnormal persistence of the subaortic conus with resorption or underdevelopment of the subpulmonary conus (infundibulum). This abnormality aligns the aorta anterior and superior with the right ventricle during development.
Causes
Causes
- The etiology for transposition of the great arteries is unknown and is presumed to be multifactorial.[1]
- The embryology likely involves abnormal persistence of the subaortic conus with resorption or underdevelopment of the infundibulum. This abnormality aligns the aorta anterior and superior with the right ventricle during development.
- Generally, TGA is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of chromosome 22q11.
References
References
- ↑ Praagh, Richard Van (2010). “Normally and Abnormally Related Great Arteries”. World Journal for Pediatric and Congenital Heart Surgery. 1 (3): 364–385. doi:10.1177/2150135110380239. ISSN 2150-1351.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4];Kristin Feeney, B.S. [5]