Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Traumatic brain injury laboratory findings
Introduction
Overview
Overview
Laboratory findings have little to no utility of diagnostic importance to the TBI. They may however, be useful, in case patient needs emergent surgery.
Laboratory Findings
Laboratory Findings
One of the rare but very interesting finding that one can see in laboratory evaluation would be hyponatremia. An elevated intracranial pressure can induce natriuresis and lead to hyponatremia in very rare cases. But otherwise, the important laboratory investigations to get complete blood count, comprehensive metabolic panel, PT/INR and PTT in case patient needs emergent surgery. CSF analysis is not done in clinical practice, as a lumbar puncture carries higher risk of herniation and the analysis itself is not particularly useful. But you can see the following abnormal findings in the CSF[1]
- Spectrin breakdown product (SBDP)120 and SBDP145
- Ubiquitin C-terminal hydrolase-L1 (UCH-L1)
- Glial fibrillary acidic protein (GFAP)
References
References
- ↑ Mondello S, Muller U, Jeromin A, Streeter J, Hayes RL, Wang KK (2011). “Blood-based diagnostics of traumatic brain injuries”. Expert Rev Mol Diagn. 11 (1): 65–78. doi:10.1586/erm.10.104. PMC 3063529. PMID 21171922.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Joanna Ekabua, M.D. [2] Deekshitha Manney, M.D.[[3]]