Trimethoprim drug interactions
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sophia Saad, Associate Editor – WikiDoc [2]
Drug Interactions
Drug Interactions
PRIMSOL may inhibit the hepatic metabolism of phenytoin. Trimethoprim, given at a common clinical dosage, increased the phenytoin half-life by 51% and decreased the phenytoin metabolic clearance rate by 30%. When administering these drugs concurrently, one should be alert for possible excessive phenytoin effect.[1]
References
References
- ↑ “PRIMSOL (TRIMETHOPRIM HYDROCHLORIDE) SOLUTION [FSC LABORATORIES, INC]”. Retrieved 9 January 2014.
Adapted from the FDA Package Insert.
Looking for the patient version?
© 2026 MyEClinic – IFTM Institut für Telematik in der Medizin GmbH