Tromantadine
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Overview
Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade name Viru-Merz. Its performance is similar to aciclovir.
Like rimantadine and amantadine, tromantadine is a derivative of adamantane.
Mechanism
Mechanism
Tromantadine inhibits the early and late events in the virus replication cycle.[1] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.
References
References
- ↑ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). “Tromantadine: inhibitor of early and late events in herpes simplex virus replication”. Antimicrob. Agents Chemother. 22 (6): 1031–6. doi:10.1128/aac.22.6.1031. PMC 185716. PMID 6297383.
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