Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Tumor lysis syndrome laboratory findings
Introduction
Overview
Overview
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum uric acid, potassium, phosphorus, and lactate dehydrogenase. Another laboratory abnormality is low calcium.[1]
Laboratory Findings
Laboratory Findings
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:[1][2]
- Blood:
- Hyperuricemia ≥ 476 μmol/l
- Hyperphosphatemia ≥ 2·1 mmol/l (children), x ≥1·45 mmol/l (adults)
- Hyperkalemia ≥ 6·0 mmol/l
- Hypocalcemia ≤ 1·75 mmol/l
- Creatinine ≥1.5 x ULN
- Lactate dehydrogenase > ULN
- Metabolic acidosis
- Low urine output
- Uric acid crystals or amorphous urates
- High uric acid-creatinine ratio > 1.0
References
References
- ↑ 1.0 1.1 Cairo MS, Bishop M (2004). “Tumour lysis syndrome: new therapeutic strategies and classification”. Br J Haematol. 127 (1): 3–11. doi:10.1111/j.1365-2141.2004.05094.x. PMID 15384972.
- ↑ Coiffier B, Altman A, Pui CH, Younes A, Cairo MS (2008). “Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review”. J Clin Oncol. 26 (16): 2767–78. doi:10.1200/JCO.2007.15.0177. PMID 18509186.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [3]