Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Turcot syndrome
Introduction
Overview
Overview
Turcot syndrome is the association between familial adenomatous polyposis and brain tumors like medulloblastoma, malignant glioma. It was first reported by Canadian surgeon Jacques Turcot (1914- ) et al in 1959 and hence carries the first author’s name.[1]
The genetic basis of Turcot syndrome is uncertain.The gene most likely to be involved is APC gene in chromosome 5q.[2] However, the syndrome has been claimed to be linked to various mutations in a number of genes. For example, the mismatch repair genes MLH1 (Online Mendelian Inheritance in Man (OMIM) 120436) or PMS2 (Online Mendelian Inheritance in Man (OMIM) 600259).
Synonyms
Synonyms
- Brain tumor-polyposis syndrome
- Glioma-polyposis syndrome