Health Dictionary
Reliable, easy-to-read patient information on common medical conditions โ written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
UCA1
Introduction
In molecular biology, Urothelial cancer associated 1 (non-protein coding), also known as UCA1, is a long non-coding RNA, it is upregulated in bladder cancer.[1] It is believed to function in regulation of embryonic development and in bladder cancer invasion and progression. It regulates the expression of several genes involved in tumourgenesis and/or embryonic development.[2]
References
References
- โ Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW, Li MQ, Chen YC, Qian XP, Lu TJ, Yu LZ, Zhang Y, Xin DQ, Na YQ, Chen WF (2006). “Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma”. Clinical Cancer Research. 12 (16): 4851โ8. doi:10.1158/1078-0432.CCR-06-0134. PMIDย 16914571.
- โ Wang F, Li X, Xie X, Zhao L, Chen W (2008). “UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion”. FEBS Letters. 582 (13): 1919โ27. doi:10.1016/j.febslet.2008.05.012. PMIDย 18501714.
Further reading
Further reading
- Xie XJ, Li X, Wang F, Chen W (2010). “้็ผ็ RNA UCA1 ๅบๅ ็็ป่ๅฎไฝๅ็ป็ป่กจ่พพ่ฐฑๅๆ” [Cellular localization and tissue expression pattern of UCA1, a non-coding RNA] (PDF). ๅๆนๅป็งๅคงๅญฆๅญฆๆฅ [Journal of Southern Medical University] (in Chinese). 30 (1): 57โ60. PMIDย 20117985.
- Kaneko K, Ito Y, Ono Y, Tainaka T, Tsuchiya H, Shimoyama Y, Ando H (2011). “Gene expression profiling reveals upregulated UCA1 and BMF in gallbladder epithelia of children with pancreaticobiliary maljunction”. Journal of Pediatric Gastroenterology and Nutrition. 52 (6): 744โ50. doi:10.1097/MPG.0b013e318214bd30. PMIDย 21593646.