UCSF-SCOR trial

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]

Official Title

University of California San Francisco (UCSF) Arteriosclerosis Specialized Center of Research (SCOR) Intervention Trial

Objective

The objective of this study is to assess the effect of the decrease in low-density lipoprotein (LDL) by diet and drug combinations on the regression of coronary lesions.

Study Description

Study Design
Allocation	Randomized
Masking	Open label
Endpoint	Mean variation in percent area stenosis
Study Details
Condition	Familial Hypercholesterolemia
Study Arms	Niacin plus colestipol +/- lovastatin (+ diet) Diet alone
Population Size	72

Outcomes

Primary Outcome

Within patient mean variation in percent area stenosis

Publications

The decrease in LDL among patients with familial hypercholesterolemia may lead to the regression of atherosclerotic lesions in the coronary arteries.^[1]

References

↑ Kane JP, Malloy MJ, Ports TA, Phillips NR, Diehl JC, Havel RJ (1990). “Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens”. JAMA. 264 (23): 3007–12. PMID 2243428.

[pmid2243428-1] Kane JP, Malloy MJ, Ports TA, Phillips NR, Diehl JC, Havel RJ (1990). “Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens”. JAMA. 264 (23): 3007–12. PMID 2243428.

[1]