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UNC13B
Introduction
Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene.[1][2]
Function
Function
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.[2]
References
References
- β Song Y, Ailenberg M, Silverman M (August 1998). “Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy”. Kidney Int. 53 (6): 1689β95. doi:10.1046/j.1523-1755.1998.00942.x. PMIDΒ 9607201.
- β 2.0 2.1 “Entrez Gene: UNC13B unc-13 homolog B (C. elegans)”.
- β Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). “Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery”. J. Biol. Chem. 272 (26): 16081β4. doi:10.1074/jbc.272.26.16081. PMIDΒ 9195900.
- β Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (September 1998). “Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process”. Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11418β22. doi:10.1073/pnas.95.19.11418. PMCΒ 21657. PMIDΒ 9736751.
- β Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N (April 2001). “Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming”. Neuron. 30 (1): 183β96. doi:10.1016/s0896-6273(01)00272-0. PMIDΒ 11343654.
- β Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (August 2002). “Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1”. J. Cell Biol. 158 (3): 577β90. doi:10.1083/jcb.200202083. PMCΒ 2173811. PMIDΒ 12163476.
- β Sakaguchi G, Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, Takai Y (July 1998). “A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13”. Biochem. Biophys. Res. Commun. 248 (3): 846β51. doi:10.1006/bbrc.1998.9067. PMIDΒ 9704016.
- β 8.0 8.1 Betz A, Okamoto M, Benseler F, Brose N (January 1997). “Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin”. J. Biol. Chem. 272 (4): 2520β6. doi:10.1074/jbc.272.4.2520. PMIDΒ 8999968.
Further reading
Further reading
- Betz A, Okamoto M, Benseler F, Brose N (1997). “Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin”. J. Biol. Chem. 272 (4): 2520β6. doi:10.1074/jbc.272.4.2520. PMIDΒ 8999968.
- Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (1997). “Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery”. J. Biol. Chem. 272 (26): 16081β4. doi:10.1074/jbc.272.26.16081. PMIDΒ 9195900.
- Sakaguchi G, Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, Takai Y (1998). “A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13”. Biochem. Biophys. Res. Commun. 248 (3): 846β51. doi:10.1006/bbrc.1998.9067. PMIDΒ 9704016.
- Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (1998). “Role of the Doc2Ξ±βMunc13β1 interaction in the neurotransmitter release process”. Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11418β22. doi:10.1073/pnas.95.19.11418. PMCΒ 21657. PMIDΒ 9736751.
- Song Y, Ailenberg M, Silverman M (1999). “Human munc13 Is a Diacylglycerol Receptor that Induces Apoptosis and May Contribute to Renal Cell Injury in Hyperglycemia”. Mol. Biol. Cell. 10 (5): 1609β19. doi:10.1091/mbc.10.5.1609. PMCΒ 30485. PMIDΒ 10233166.
- Duncan RR, Betz A, Shipston MJ, Brose N, Chow RH (1999). “Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo”. J. Biol. Chem. 274 (39): 27347β50. doi:10.1074/jbc.274.39.27347. PMIDΒ 10488064.
- Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N (2001). “Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming”. Neuron. 30 (1): 183β96. doi:10.1016/S0896-6273(01)00272-0. PMIDΒ 11343654.
- Schoch S, Castillo PE, Jo T, Mukherjee K, Geppert M, Wang Y, Schmitz F, Malenka RC, SΓΌdhof TC (2002). “RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone”. Nature. 415 (6869): 321β6. doi:10.1038/415321a. PMIDΒ 11797009.
- Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (2002). “Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1”. J. Cell Biol. 158 (3): 577β90. doi:10.1083/jcb.200202083. PMCΒ 2173811. PMIDΒ 12163476.
- Sheu L, Pasyk EA, Ji J, Huang X, Gao X, Varoqueaux F, Brose N, Gaisano HY (2003). “Regulation of insulin exocytosis by Munc13-1”. J. Biol. Chem. 278 (30): 27556β63. doi:10.1074/jbc.M303203200. PMIDΒ 12871971.
- Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R (2004). “The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis”. Mol. Endocrinol. 18 (1): 117β26. doi:10.1210/me.2003-0300. PMIDΒ 14593078.
- Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). “Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions”. Genome Res. 14 (9): 1711β8. doi:10.1101/gr.2435604. PMCΒ 515316. PMIDΒ 15342556.
- Yamamoto K, Ishii E, Sako M, Ohga S, Furuno K, Suzuki N, Ueda I, Imayoshi M, Yamamoto S, Morimoto A, Takada H, Hara T, Imashuku S, Sasazuki T, Yasukawa M (2005). “Identification of novel MUNC13-4 mutations in familial haemophagocytic lymphohistiocytosis and functional analysis of MUNC13-4-deficient cytotoxic T lymphocytes”. J. Med. Genet. 41 (10): 763β7. doi:10.1136/jmg.2004.021121. PMCΒ 1735600. PMIDΒ 15466010.
- Speight P, Silverman M (2005). “Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34”. Traffic. 6 (10): 858β65. doi:10.1111/j.1600-0854.2005.00321.x. PMIDΒ 16138900.