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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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UNC93A

Introduction

Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.[1]

Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.[2][3] It belongs to the atypical SLCs that was recently listed.[2] It is therefore presumed that UNC93A is a transporter protein.

UNC93A is closely related to Unc93B1 and MFSD11.[4][5]

UNC93A is affected by amino acid deprivation in cell cortex cultures[3][4] and starvation in in vivo samples.[4]

It is expressed in neurons, with staining close to the plasma membrane.[4]

Read also [6][7] for functional studies in C.elegans.

References

References

  1. ↑ “Entrez Gene: Unc-93 homolog A (C. elegans)”.
  2. ↑ 2.0 2.1 Perland E, Fredriksson R (March 2017). “Classification Systems of Secondary Active Transporters”. Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  3. ↑ 3.0 3.1 Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). “Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression”. Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
  4. ↑ 4.0 4.1 4.2 4.3 Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). “The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice”. Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
  5. ↑ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). “The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis”. PLOS One. 11 (6): e0156912. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
  6. ↑ Levin JZ, Horvitz HR (April 1992). “The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction”. The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
  7. ↑ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). “sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans”. The Journal of Neuroscience. 23 (27): 9133–45. PMID 14534247.
Further reading

Further reading