Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
UPP1
Introduction
Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene.[1][2][3]
Interactive pathway map
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Fluorouracil (5-FU) Activity edit
- ↑ The interactive pathway map can be edited at WikiPathways: “FluoropyrimidineActivity_WP1601”.
References
References
- ↑ Denney RM, Nichols EA, Ruddle FH (September 1979). “Assignment of a gene for uridine phosphorylase to chromosome 7”. Cytogenet Cell Genet. 22 (1–6): 195–9. doi:10.1159/000130934. PMID 752472.
- ↑ Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T (January 2002). “Expression of uridine and thymidine phosphorylase genes in human breast carcinoma”. Int J Cancer. 97 (5): 631–5. doi:10.1002/ijc.10105. PMID 11807789.
- ↑ “Entrez Gene: UPP1 uridine phosphorylase 1”.
- ↑ Russell, R L; Cao D; Zhang D; Handschumacher R E; Pizzorno G (April 2001). “Uridine phosphorylase association with vimentin. Intracellular distribution and localization”. J. Biol. Chem. United States. 276 (16): 13302–7. doi:10.1074/jbc.M008512200. ISSN 0021-9258. PMID 11278417.
Further reading
Further reading
- Pizzorno G, Cao D, Leffert JJ, et al. (2002). “Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update”. Biochim. Biophys. Acta. 1587 (2–3): 133–44. doi:10.1016/s0925-4439(02)00076-5. PMID 12084455.
- Watanabe S, Uchida T (1995). “Cloning and expression of human uridine phosphorylase”. Biochem. Biophys. Res. Commun. 216 (1): 265–72. doi:10.1006/bbrc.1995.2619. PMID 7488099.
- Russell RL, Cao D, Zhang D, et al. (2001). “Uridine phosphorylase association with vimentin. Intracellular distribution and localization”. J. Biol. Chem. 276 (16): 13302–7. doi:10.1074/jbc.M008512200. PMID 11278417.
- Miyashita H, Takebayashi Y, Eliason JF, et al. (2002). “Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma”. Cancer. 94 (11): 2959–66. doi:10.1002/cncr.10568. PMID 12115385.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS…9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Temmink OH, de Bruin M, Laan AC, et al. (2006). “The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells”. Int. J. Biochem. Cell Biol. 38 (10): 1759–65. doi:10.1016/j.biocel.2006.04.007. PMID 16798057.