Ulcerative colitis historical perspective

The first case of ulcerative colitis was reported by Sir Samuel Wilks in 1859. He even coined the term ulcerative colitis and submitted the histopathological slides for the first time in his case report. It was believed that Prince Charles, young pretender of the roman empire, suffered from ulcerative colitis and cured himself by adopting a milk-free diet. In 1885, Allchin gave a detailed description of ulcerative colitis for the first time. Based on the work by Allchin, Hale-White in 1888, differentiated ulcerative colitis from Crohn’s disease.^[1]

• In 1745, Prince Charles suffered from ulcerative colitis and cured himself by adopting a milk-free diet.^[1]
• In 1859, Sir Samuel Wilks first used the term ulcerative colitis in a case report even produced photomicrographs showing the histological appearances, an outstanding technical achievement for the time.
• In 1885, Allchin gave a detailed description of ulcerative colitis for the first time.
• In 1888, Hale-White worked on the study done by Allchin and differentiated ulcerative colitis from Crohn’s disease.
• In 1965, Evans & Acheson suggested that ulcerative colitis afflicts roughly 1 in 1000 of the general population.

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