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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Ureaplasma urealyticum medical therapy

Introduction

Overview

Overview

Antibiotics are the mainstay of treatment for Ureaplasma infection, and antibiotic susceptibility testing is advised prior to treatment due to geographical differences in antibiotic resistance pattern. Doxycycline is recommended as the drug of first choice in non-pregnant women and adults. Josamycin is often recommended for neonates and pregnant women, especially when mixed infection is present. Clarithromycin and pristinamycin are also effective for treating Ureaplasma infection.[1][2][3]

Medical Therapy

Medical Therapy

Antibiotics are the mainstay of treatment for Ureaplasma infection. Antibiotic susceptibility testing should be done to avoid treatment failure because of the geographical differences in antibiotic resistance.

Recommended antibiotics[1][2][3]

  1. This is the drug of first choice.
  2. It is the most active tetracycline for Mycoplasma and Ureaplasma infection.
  3. It should be avoided in pregnant women and young children.
  1. Josamycin and clarithromycin are the most effective macrolides against Ureaplasma infection.
  2. Josamycin is often recommended for neonates and pregnant women, especially when mixed infection is present.
  3. Pristinamycin can be used as an alternative to Josamycin in pregnant women.
  4. Erythromycin has a low efficacy against Ureaplasma urealyticum.
  • Fluoroquinolones: They have a low efficacy against urogenital Mycoplasma and Ureaplasma infection.
  • Clindamycin: This has also been demonstrated to have a low efficacy against Ureaplasma species.
References

References

  1. ↑ 1.0 1.1 De Francesco MA, Caracciolo S, Bonfanti C, Manca N (2013). “Incidence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum isolated in Brescia, Italy, over 7 years”. J Infect Chemother. 19 (4): 621–7. doi:10.1007/s10156-012-0527-z. PMID 23192735.
  2. ↑ 2.0 2.1 Resch B, Gutmann C, Reiterer F, Luxner J, Urlesberger B (2016). “Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics”. Infection. 44 (3): 323–7. doi:10.1007/s15010-015-0858-7. PMID 26518581.
  3. ↑ 3.0 3.1 Lee MY, Kim MH, Lee WI, Kang SY, Jeon YL (2016). “Prevalence and Antibiotic Susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in Pregnant Women”. Yonsei Med J. 57 (5): 1271–5. doi:10.3349/ymj.2016.57.5.1271. PMC 4960396. PMID 27401661.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fatimo Biobaku M.B.B.S [2]