Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Venoocclusive disease
Introduction
For patient information, click here
Synonyms and Keywords: VOD, sinuosoidal obstruction syndrome
Overview
Overview
Veno-occlusive disease (VOD) is a disease of the liver in which the veins in the liver are obstructed or blocked. VOD is a complication that occurs in up to 25% of bone marrow transplantations, and may also occur after ingestion of certain plant alkaloids.
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Historical Perspective
Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.
References
Classification
Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.
References
Pathophysiology
Please help WikiDoc by adding more content here. It’s easy! Click here to learn about editing.
Overview
Pathophysiology
VOD is also known as sinuosoidal obstruction syndrome due to obstruction of the venous system. Following bone marrow transplantation, VOD has been hypothesized to be due to injury to the hepatic venous endothelium from the conditioning regimen.
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Causes
Drug induced
Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.
References
Differentiating Veno-occlusive disease from other Diseases
Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.
References
Epidemiology and Demographics
Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.
References
Risk Factors
Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.
References
Screening
Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.
References
Natural History, Complications and Prognosis
Please help WikiDoc by adding more content here. It’s easy! Click here to learn about editing.
Overview
Prognosis
When associated with bone marrow transplant, VOD is fatal in over 30% of cases. Cases due to plant alkaloids often have a longer and more unpredictable course.
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Diagnosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Abdominal X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]