Veno-occlusive disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Veno-occlusive disease (VOD) is a disease of the liver in which the veins in the liver are obstructed or blocked. VOD is a complication that occurs in up to 25% of bone marrow transplantations, and may also occur after ingestion of certain plant alkaloids.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

VOD is also known as sinuosoidal obstruction syndrome due to obstruction of the venous system. Following bone marrow transplantation, VOD has been hypothesized to be due to injury to the hepatic venous endothelium from the conditioning regimen.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

When associated with bone marrow transplant, VOD is fatal in over 30% of cases. Cases due to plant alkaloids often have a longer and more unpredictable course.

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