It is unclear exactly why certain babies are born with septal defects. There is evidence to suggest that families with a history of genetic problems and other congenital heart disease may be at an increased risk for carrying and expressing the trait. Genetic testing may be performed to assist you in estimating the likelihood that any future children may be born with defect.^[1]

During pregnancy, drug and alcohol exposure can also harm the fetus during development and result in potential birth defects.