Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Vesicular monoamine transporters
Introduction
Overview
Overview
The vesicular monoamine transporter is a transport protein located within the presynaptic cell.
Substrates
Substrates
Substrates for the transporter is mainly noradrenaline, adrenaline and isoprenaline. However, other substrates include dopamine, 5-HT, guanethidine and MPP+.[1]
Clinicial significance
Clinicial significance
It can be inhibited by reserpine and tetrabenazine.[1]
VMAT is the main target of methamphetamine. By acting as a competitive antagonist, methamphetamine blocks the presynaptic cell’s ability to use VMAT to package the above mentioned neurotransmitters into vesicles. The result is increased neurotransimtter release that is not dependent on the phasic activity of the presynaptic cell.
References
References
- ↑ 1.0 1.1 Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 167
Further reading
Further reading
- Kilbourn MR (1997). “In vivo radiotracers for vesicular neurotransmitter transporters”. Nucl. Med. Biol. 24 (7): 615–9. PMID 9352531.
- Weihe E, Eiden LE (2000). “Chemical neuroanatomy of the vesicular amine transporters”. FASEB J. 14 (15): 2435–49. doi:10.1096/fj.00-0202rev. PMID 11099461.
External links
External links
- Vesicular+Monoamine+Transport+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]