Von Willebrand disease history and symptoms

Patients with von Willebrand disease present with history of mucosal bleeding, recurrent nose bleeds, oral cavity bleeding, and positive family history of similer symptoms among other family members. Adults patients with vWD mainly present with bleeding after dental extraction/ or other surgery. Heavy menstrual periods and postpartum hemorrhage are common among affected females with von Willebrand’s disease. Severe internal or joint bleeding can occur but is usually rare.

Patients with von Willebrand disease may have a positive history of:^[1]

• Personal bleeding
• Family history of bleeding
• Bruising without obvious trauma
• Recurrent nose bleeds
• Oral cavity bleeding
• Bleeding from the gums after brushing or flossing teeth
• Prolonged bleeding following dental cleaning or extractions

Common symptoms of von Willebrand disease include:^[2]

• Easy bruising
• Nosebleeds
• Oral cavity bleeding
• Bleeding after dental extraction/surgery
• Heavy menstrual periods
• Postpartum hemorrhage
• Epistaxis

Less common symptoms of von Willebrand’s disease include^[3]

• Severe internal bleeding
• Joint bleeding
• Gastrointestinal bleeding

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