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WDR83
Introduction
WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene. [1]
Function
Function
This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.
Further reading
Further reading
- Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). “Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis”. RNA. 8 (4): 426–39. PMC 1370266. PMID 11991638.
- Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ (2004). “Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists”. Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6981–6. doi:10.1073/pnas.0305894101. PMC 406452. PMID 15118098.
- Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G (2006). “The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)”. J. Biol. Chem. 281 (13): 8645–55. doi:10.1074/jbc.M513751200. PMID 16407229.
- Haase D, Keiner S, Mawrin C, Wolf G (2009). “Reduced Morg1 expression in ischemic human brain”. Neurosci. Lett. 455 (1): 46–50. doi:10.1016/j.neulet.2009.03.048. PMID 19429104.
- Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL, Kong X, Gao QY, Wei LP, Fang JY (2012). “Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer”. Cell Res. 22 (9): 1374–89. doi:10.1038/cr.2012.57. PMC 3434345. PMID 22491477.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.