WT limb blood syndrome

WT limb-blood syndrome is a rare syndrome characterized by hematological and musculoskeletal anomalies often appearing in childhood.

WT limb-blood syndrome is named after two families with surnames starting with W and T, in which multiple members had features characteristic of the disease.

WT limb-blood syndrome has an autosomal dominant pattern of inheritance.

• Fanconi anemia
• Leukemia
• Lymphoma

WT limb-blood syndrome is differentiated from Fanconi anemia by the autosomal dominant pattern of inheritance and absence of chromosome breakage.

• The prevalence of this disease is <0.1/100 000.
• The disease often appears in childhood.

• Syndactyly
• Bifid or hypoplastic thumbs
• Ulnar and radial defects

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