Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
WT limb blood syndrome
Introduction
Overview
Overview
WT limb-blood syndrome is a rare syndrome characterized by hematological and musculoskeletal anomalies often appearing in childhood.
Historical Perspective
Historical Perspective
WT limb-blood syndrome is named after two families with surnames starting with W and T, in which multiple members had features characteristic of the disease.
Pathophysiology
Pathophysiology
Genetics
WT limb-blood syndrome has an autosomal dominant pattern of inheritance.
Associated Conditions
Differentiating from other Disease
Differentiating from other Disease
WT limb-blood syndrome is differentiated from Fanconi anemia by the autosomal dominant pattern of inheritance and absence of chromosome breakage.
Epidemiology and Demographics
Epidemiology and Demographics
- The prevalence of this disease is <0.1/100 000.
- The disease often appears in childhood.
Diagnosis
Diagnosis
Physical Examination
Extremities
- Syndactyly
- Bifid or hypoplastic thumbs
- Ulnar and radial defects
References
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]