Granulomatosis with polyangiitis laboratory findings

Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts.

Laboratory findings consistent with the diagnosis of Granulomatosis with polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated creatinine serum, erythrocyte sedimentation rate, C reactive protein, proteinuria, microscopic hematuria, and red blood casts.

• Complete blood count
• Serum Creatinine
• Blood urea nitrogen
• Anti-neutrophil cytoplasmic antibody test
  • Anti PR3

• Proteinuria
• Microscopic hematuria
• Red cell casts

Renal biopsy is the gold standard in establishing Granulomatosis with polyangiitis.^[1] Renal biopsy reveals under electron microscopy:

• Subendothelial edema

• Microthrombosis, and
• Degranulation of neutrophils.

Under light microscopy, necrotizing and crescentic glomerulonephritis is seen. ^[2]