Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Wegener's granulomatosis risk factors

Introduction

Overview

Overview

Common risk factors in the development of granulomatosis with polyangitis(GPA) are age group of 40-65 years and presence of variant HLA-DPB1*0401 with ANCA.

Risk Factors

Risk Factors

Common Risk Factors

  • Common risk factors in the development of granulomatosis with polyangitis(GPA) include:
    • Age= 40-65 years
    • Genetic= HLA DPB1[1]
      • Variant  HLA-DPB1*0401 in those associated with ANCA [2][3]
    • Infection leading to granulomas[4]

Less Common Risk Factors

  • Less common risk factors in the development of granulomatosis with polyangitis(GPA) include:
    • Exposure to silica[5]
References

References

  1. ↑ Wieczorek S, Holle JU, Epplen JT (January 2010). “Recent progress in the genetics of Wegener’s granulomatosis and Churg-Strauss syndrome”. Curr Opin Rheumatol. 22 (1): 8–14. doi:10.1097/BOR.0b013e3283331151. PMID 19864953.
  2. ↑ https://ghr.nlm.nih.gov/condition/granulomatosis-with-polyangiitis#sourcesforpage
  3. ↑ Jagiello P, Gencik M, Arning L, Wieczorek S, Kunstmann E, Csernok E, Gross WL, Epplen JT (April 2004). “New genomic region for Wegener’s granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes”. Hum. Genet. 114 (5): 468–77. doi:10.1007/s00439-004-1092-z. PMID 14968360.
  4. ↑ Spagnolo P, Richeldi L, du Bois RM (December 2008). “Environmental triggers and susceptibility factors in idiopathic granulomatous diseases”. Semin Respir Crit Care Med. 29 (6): 610–9. doi:10.1055/s-0028-1101271. PMID 19221959.
  5. ↑ Hogan SL, Cooper GS, Savitz DA, Nylander-French LA, Parks CG, Chin H, Jennette CE, Lionaki S, Jennette JC, Falk RJ (March 2007). “Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control study”. Clin J Am Soc Nephrol. 2 (2): 290–9. doi:10.2215/CJN.03501006. PMC 4049534. PMID 17699427.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Amandeep Singh M.D.[3]