Some patients with Whipple’s disease may have abnormal hematological findings and elevated acute phase reactants, which is suggestive of the infection. Biopsy of the affected tissue is important to confirm the diagnosis. Laboratory evidence of malabsorption including hypoalbuminemia, hypokalemia, hypocalcemia, hypomagnesemia may be seen.

Laboratory findings associated with the Whipple’s are findings related to infection, chronic disease, and malabsorption.^{[1][2][3][4][5][6][7][8][9][10][11][12]}

• Elevated level of acute phase reactants
  • Elevated erythrocyte sedimentation rate (ESR)
  • Elevated C-reactive protein (CRP)
• Hematological findings include:
  • Anemia due to intestinal blood loss, iron deficiency, and vitamin B12 and folic acid malabsorption
  • Leukocytosis
  • Thrombocytosis/Thrombocytopenia
• Laboratory evidence of malabsorption may be seen:
  • Hypoalbuminemia
  • Hypokalemia
  • Hypocalcemia
  • Hypomagnesemia

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