Whipple's disease risk factors

Common risk factors in the development of Whipple’s disease may be environmental, genetic, and immunologic. The most important risk factor in the development of Whipple’s disease is poor sanitation including living in homeless shelters and absence of toilets. Defective cellular immunity is the less common risk factor.

• Risk factors in the development of Whipple’s disease may be environmental, genetic, and immunologic.^{[1][2][3][4][5][6][7][8][9][10]}

• The most potent risk factor in the development of Whipple’s disease is poor sanitation including living in homeless shelters and absence of toilets.

• Common risk factors in the development of Whipple’s disease include:
  • Poor sanitation
  • Living in homeless shelters
  • Absence of toilets
  • Sewage influxed plants
  • Close contact with patients or chronic carriers

• Less common risk factors in the development of Whipple’s disease include:
  • Genetic predisposition including HLA DRB1*13 and HLA DQB1*06 positive
  • HIV infection
  • Immunosuppressed patients

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