Wigglesworthia glossinidia brevipalpis is a Gram-negative bacterium in the family Enterobacteriaceae, related to E. coli, which lives in the gut of the tsetse fly. The bacterium bears the name of the British entomologist who first described it, Sir Vincent Brian Wigglesworth. Wigglesworthia has symbiotically co-evolved with the tsetse fly for millions of years, and is a text book example of a bacterial endosymbiont. Because of this relationship, Wigglesworthia has lost a large part of its genome and has one of the smallest known genomes of any living organism. Together with Buchnera aphidicola, Wigglesworthia has been the subject of genetic research into the minimal genome necessary for any living organism. Wigglesworthia also synthesizes key vitamins which the tsetse fly does not get from its diet of blood. Without the vitamins Wigglesworthia produces, the tsetse fly cannot reproduce. Since the tsetse fly spreads african sleeping sickness, Wigglesworthia may one day be used to control the spread of this terrible disease.

• Genome News Network article on Wigglesworthia
• 2can bioinformatics reference on Wigglesworthia
• University of Bath minimal genome research
• Wigglesworthia glossinidia brevipalpis complete proteome