Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Wilms' tumor risk factors
Introduction
Overview
Overview
Common risk factors in the development of wilms tumor include familial wilms tumor, congenital anomalies, WT-1 related syndromes and WT2-related syndromes. Less common risk factors in the development of wilms tumor include perlman syndrome, simpson-golabi-ehemel syndrome, Sotos syndrome, 9q22.3 microdeletion syndrome, Bloom syndrome, li-fraumeni syndrome and Alagille syndrome.
Risk factors
Risk factors
Common Risk Factors
- Common risk factors in the development of wilms tumor include:
- Familial Wilms tumor [1]
- Congenital anomaly
- Hemihyperplasia
- Urinary tract anomalies, including cryptorchidism and hypospadias
- Aniridia
- WT1-related syndromes include the following:[2]
- WAGR syndrome
- Denys-Drash syndrome and Frasier syndrome
- WT2-related syndromes include the following:
Less Common Risk Factors
- Less common risk factors in the development of wilms tumor include:
- Other syndromes include the following:
- Perlman syndrome[4]
- Simpson-Golabi-Behemel syndrome[5]
- Sotos syndrome[6]
- 9q22.3 microdeletion syndrome
- Bloom syndrome[7]
- Li-Fraumeni syndrome[8]
- Alagille syndrome[9]
- Other syndromes include the following:
References
References
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq
- ↑ Crider-Miller SJ, Reid LH, Higgins MJ, Nowak NJ, Shows TB, Futreal PA, Weissman BE (December 1997). “Novel transcribed sequences within the BWS/WT2 region in 11p15.5: tissue-specific expression correlates with cancer type”. Genomics. 46 (3): 355–63. doi:10.1006/geno.1997.5061. PMID 9441738.
- ↑ Morris MR, Astuti D, Maher ER (May 2013). “Perlman syndrome: overgrowth, Wilms tumor predisposition and DIS3L2”. Am J Med Genet C Semin Med Genet. 163C (2): 106–13. doi:10.1002/ajmg.c.31358. PMID 23613427.
- ↑ Alton KB, Patrick JE, Shaw C, McGuire JL (1975). “Comparative biotransformation of triflubazam in rats, dogs, and monkeys”. Drug Metab. Dispos. 3 (6): 445–52. PMID 1219.
- ↑ Heller BR, Walsh FJ (January 1976). “Changing nursing students’ attitudes toward the aged: an experimental study”. J Nurs Educ. 15 (1): 9–17. PMID 1479.
- ↑ Berger C, Frappaz D, Leroux D, Blez F, Vercherat M, Bouffet E, Jalbert P, Brunat-Mentigny M (August 1996). “[Wilms tumor and Bloom syndrome]”. Arch Pediatr (in French). 3 (8): 802–5. PMID 8998536.
- ↑ Hartley AL, Birch JM, Tricker K, Wallace SA, Kelsey AM, Harris M, Jones PH (June 1993). “Wilms’ tumor in the Li-Fraumeni cancer family syndrome”. Cancer Genet. Cytogenet. 67 (2): 133–5. PMID 8392435.
- ↑ Bourdeaut F, Guiochon-Mantel A, Fabre M, Martelli H, Patte C, Porta G, Bernard O, Delattre O, Jacquemin E (April 2008). “Alagille syndrome and nephroblastoma: Unusual coincidence of two rare disorders”. Pediatr Blood Cancer. 50 (4): 908–11. doi:10.1002/pbc.21255. PMID 17584876.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2],Shanshan Cen, M.D. [3]