Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Wilson's disease natural history, complications and prognosis
Introduction
Overview
Overview
If left untreated, Wilson’s disease will lead to death as the copper accumulation in the liver and brain will lead to cirrhosis and severe dystonia respectively. Common complications of Wilson’s disease include hepatocellular carcinoma, renal failure, and persistent neurological manifestations. Prognosis of Wilson’s disease is usually good in case of early detection and proper treatment.
Natural History, Complications, and Prognosis
Natural History, Complications, and Prognosis
Natural history
- The symptoms of Wilson’s disease usually develop between age of 5 and 35 years. However, the symptoms can be presented at any age onset.
- If left untreated, Wilson’s disease will lead to death. The copper accumulation in the liver and the brain will end up with cirrhosis and severe dystonia respectively. [1]
Complications
- Common complications of Wilson’s disease include the following:
- Cirrhosis
- Hepatocellular carcinoma
- Persistent the neurological manifestations
- Renal complications as kidney stones and renal failure
- Hemolytic anemia
Prognosis
- Prognosis of Wilson’s disease is usually good with early detection and proper treatment except in the severely advanced patients.
References
References
- ↑ European Association for Study of Liver (2012). “EASL Clinical Practice Guidelines: Wilson’s disease”. J Hepatol. 56 (3): 671–85. doi:10.1016/j.jhep.2011.11.007. PMID 22340672.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]